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Scarpulla RC

doi:10.1080/21645515.2017.1415684 Ho K, Melanson M, Desai JA

The FDA can take it or leave it," Tatem noted

It is classified as primary (polycythemia vera, D45), secondary (reactive elevation from hypoxia, EPO excess, or other causes

Without sufficient NAD+, these enzymes cannot functionwhich explains why the decline in NAD+ with age leads to a cascade of cellular dysfunctions (Katsyuba et al., Nat Metab 2020)